IL2RA

Across TCGA pan-cancer cohorts, IL2RA RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of IL2RA’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where IL2RA RNA is more highly expressed in tumor relative to normal tissue. In most cancer types IL2RA is over-expressed in tumor.

HNSC, KIRC, and LUAD are the cancer types where IL2RA tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IL2RA RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	II,III,IV	+1.494	<.001	12	view →
KIRC	All	IV	+1.322	<.001	11	view →
LUAD	Male	All	+1.479	<.001	9	view →
STAD	Female	All	+2.047	<.001	8	view →
BRCA	All	All	+0.374	.003	4	view →
LUSC	All	All	+0.811	<.001	3	view →
ESCA	All	All	+1.912	.002	2	view →
CHOL	Female	All	+1.710	.007	2	view →
COAD	All	II,III,IV	+0.473	.010	2	view →
UCEC	All	All	+0.456	.020	2	view →
LIHC	Female	II,III,IV	+0.452	.014	2	view →
PRAD	All	All	+0.274	.035	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

IL2RA–HNSC

Open the HNSC breakdown →