IL2RA

Across TCGA cell cohorts, IL2RA mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible IL2RA-associated genes across cancer lineages are GPR42, TMEM207, and CXorf51A. Each is linked with IL2RA in more than 1 cancer types. Because this analysis shows association rather than direction, both IL2RA-to-partner and partner-to-IL2RA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GPR42 grouped by IL2RA-low versus IL2RA-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IL2RA→partner) and Y-score (partner→IL2RA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	GPR42 →	+0.016	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	TMEM207 →	+0.095	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	CXorf51A →	+0.055	+4.887	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

GPR42 by IL2RA expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →