IL27RA

Across TCGA patient cohorts, IL27RA mutation is significantly associated with the RNA expression of many other genes, with 1,028 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IL27RA-associated genes across cancer lineages are MTCYBP10, MIR6088, and GABRG3-AS1. Each is linked with IL27RA in more than 2 cancer types. Because this analysis shows association rather than direction, both IL27RA-to-partner and partner-to-IL27RA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MTCYBP10 grouped by IL27RA-low versus IL27RA-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IL27RA→partner) and Y-score (partner→IL27RA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	MTCYBP10 →	+0.075	+4.289	<.001	.007	3	3
COAD	MIR6088 →	+0.634	+3.843	<.001	.004	3	3
CESC	GABRG3-AS1 →	+0.029	+4.812	.002	.006	3	2
SKCM	DPP9 →	+0.440	+3.732	.004	<.001	3	2
SKCM	MPC2 →	+0.538	+3.425	<.001	.004	3	2
UCEC	NTAN1 →	+0.532	+3.301	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,028 associations by consensus.

MTCYBP10 by IL27RA expression — BLCA

Explore this box plot interactively →