IL27RA

Across TCGA patient cohorts, IL27RA mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IL27RA-associated genes across cancer lineages are MSH2, mTOR_pS2448, and Annexin_VII. Each is linked with IL27RA in more than 1 cancer types. Because this analysis shows association rather than direction, both IL27RA-to-partner and partner-to-IL27RA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MSH2 grouped by IL27RA-low versus IL27RA-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IL27RA→partner) and Y-score (partner→IL27RA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MSH2 →	-0.297	-2.449	.001	.019	3	2
UCEC	mTOR_pS2448 →	-0.163	-2.986	.008	.035	3	2
UCEC	Annexin_VII →	-0.155	-2.449	.006	.019	3	2
UCEC	Caspase-7-cleavedD198 →	+0.783	+2.019	.001	.017	3	2
UCEC	ERK2 →	+0.252	+3.000	.001	.001	3	1
UCEC	GAPDH →	+0.442	+1.807	.046	.027	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

MSH2 by IL27RA expression — UCEC

Explore this box plot interactively →