IL24

Across TCGA patient cohorts, IL24 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IL24-associated genes across cancer lineages are JNK_pT183_Y185, Annexin-1, and STAT3_pY705. Each is linked with IL24 in more than 1 cancer types. Because this analysis shows association rather than direction, both IL24-to-partner and partner-to-IL24 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK_pT183_Y185 grouped by IL24-low versus IL24-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IL24→partner) and Y-score (partner→IL24) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.170	-3.000	.036	.036	3	1
UCEC	Annexin-1 →	+0.542	+2.827	.033	.035	3	1
UCEC	STAT3_pY705 →	-0.398	-3.584	.001	.002	3	1
UCEC	ATM →	-0.648	-3.584	.003	.002	3	1
UCEC	4E-BP1 →	+0.328	+2.837	.012	.035	3	1
UCEC	Caveolin-1 →	-0.969	-3.321	.005	.010	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

JNK_pT183_Y185 by IL24 expression — UCEC

Explore this box plot interactively →