IL23A

Across TCGA patient cohorts, IL23A protein abundance is significantly associated with the RNA expression of many other genes, with 2,956 significant associations in total. GBM shows the largest number of these associations.

The most reproducible IL23A-associated genes across cancer lineages are SNRPD3, PRODH, and SEZ6L. Each is linked with IL23A in more than 1 cancer types. Because this analysis shows association rather than direction, both IL23A-to-partner and partner-to-IL23A results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IL23A versus SNRPD3 in GBM, with a Pearson correlation of 0.28.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IL23A→partner) and Y-score (partner→IL23A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SNRPD3 →	+0.360	+0.524	.006	.004	3	1
GBM	PRODH →	+1.187	+0.641	<.001	<.001	3	1
GBM	SEZ6L →	+1.511	+0.573	.007	.009	3	1
GBM	LGALS1 →	-0.913	-0.722	.001	.002	3	1
GBM	SEPTIN3 →	+1.355	+0.846	<.001	<.001	3	1
GBM	KDELR3 →	-0.480	-0.534	.002	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,956 associations by consensus.

IL23A vs SNRPD3 — GBM

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