IL23A

Across TCGA pan-cancer cohorts, IL23A RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated IL23A data layer compared with 2 for mutation status.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher IL23A RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated IL23A expression acts as an unfavorable survival marker, although some lineages such as HNSC and UCEC show a favorable association.

KIRC, ACC, and HNSC are the cancer types where IL23A RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	All	0.528	0.719	<.001	146	view →
ACC	OS	Median	All	0.443	0.783	<.001	91	view →
HNSC	OS	Tertile	II,III,IV	0.459	0.267	.006	59	view →
KICH	OS	Median	II,III,IV	0.747	1.000	.004	51	view →
KIRP	OS	Quartile	II,III,IV	0.154	1.000	.003	47	view →
UCEC	OS	Median	III,IV	0.888	0.761	.005	38	view →
SKCM	OS	Tertile	All	0.428	0.294	.001	37	view →
MESO	DFS	Median	III,IV	0.210	0.626	.004	36	view →
STAD	OS	Median	IV	0.625	0.175	.002	33	view →
SCLC	OS	Tertile	All	0.653	0.364	.007	31	view →
BLCA	OS	Tertile	III,IV	0.474	0.296	.015	19	view →
LUAD	OS	Median	All	0.249	0.435	.006	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

IL23A–KIRC (DFS)

Open the KIRC breakdown →