IL23A

Across TCGA patient cohorts, IL23A mutation is significantly associated with the RNA expression of many other genes, with 605 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IL23A-associated genes across cancer lineages are RN7SL447P, CPSF7, and GUF1. Each is linked with IL23A in more than 1 cancer types. Because this analysis shows association rather than direction, both IL23A-to-partner and partner-to-IL23A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL447P grouped by IL23A-low versus IL23A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IL23A→partner) and Y-score (partner→IL23A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RN7SL447P →	+0.273	+3.681	<.001	<.001	3	2
UCEC	CPSF7 →	+0.621	+3.354	<.001	.005	3	1
UCEC	GUF1 →	+0.680	+3.332	<.001	.005	3	1
UCEC	MIER3 →	+0.841	+3.332	<.001	.005	3	1
UCEC	GNAQ →	+0.692	+3.354	.004	.005	3	1
UCEC	TYW5 →	+0.532	+3.332	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 605 associations by consensus.

RN7SL447P by IL23A expression — UCEC

Explore this box plot interactively →