IL22

Across TCGA patient cohorts, IL22 RNA expression is significantly associated with the protein abundance of many other proteins, with 7,491 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible IL22-associated proteins across cancer lineages are LPXN, ADA2, and DOCK2. Each is linked with IL22 in more than 7 cancer types. Because this analysis shows association rather than direction, both IL22-to-partner and partner-to-IL22 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IL22 versus LPXN in LSCC, with a Pearson correlation of 0.55.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (IL22→partner) and Y-score (partner→IL22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	LPXN →	+0.600	+0.441	<.001	<.001	3	8
LSCC	ADA2 →	+0.544	+0.287	<.001	<.001	3	8
LSCC	DOCK2 →	+0.608	+0.479	<.001	<.001	3	8
GBM	GRAP2 →	+0.690	+0.121	<.001	<.001	3	8
LSCC	ARHGAP25 →	+0.580	+0.441	<.001	<.001	3	7
LSCC	ARHGAP45 →	+0.529	+0.289	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,491 associations by consensus.

IL22 vs LPXN — LSCC

Explore this scatter interactively →