IL22

Across TCGA patient cohorts, IL22 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,454 significant associations in total. KIRC shows the largest number of these associations.

The most reproducible IL22-associated GO terms across cancer lineages are B cell mediated immunity, Antigen receptor-mediated signaling pathway, and CD4-positive, alpha-beta T cell activation. Each is linked with IL22 in more than 18 cancer types. Because this analysis shows association rather than direction, both IL22-to-partner and partner-to-IL22 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, B cell mediated immunity grouped by IL22-low versus IL22-high in THCA.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IL22→partner) and Y-score (partner→IL22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
THCA	B cell mediated immunity →	+0.068	+0.016	<.001	<.001	3	19
LAML	Antigen receptor-mediated signaling pathway →	+0.059	+0.180	<.001	<.001	3	18
BRCA	CD4-positive, alpha-beta T cell activation →	+0.039	+0.028	<.001	<.001	3	18
BRCA	Positive regulation of leukocyte cell-cell adhesion →	+0.042	+0.027	<.001	<.001	3	17
KIRC	Regulation of cysteine-type endopeptidase activity involved in apoptotic process →	+0.034	+0.067	<.001	<.001	3	17
LAML	T cell receptor signaling pathway →	+0.050	+0.168	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,454 associations by consensus.

B cell mediated immunity by IL22 expression — THCA

Explore this box plot interactively →