IL22

Across TCGA patient cohorts, IL22 protein abundance is significantly associated with the RNA expression of many other genes, with 7,986 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible IL22-associated genes across cancer lineages are TMPO, MIR223HG, and CASS4. Each is linked with IL22 in more than 3 cancer types. Because this analysis shows association rather than direction, both IL22-to-partner and partner-to-IL22 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IL22 versus TMPO in PDAC, with a Pearson correlation of 0.53.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IL22→partner) and Y-score (partner→IL22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	TMPO →	+0.842	+1.087	.001	<.001	3	4
GBM	MIR223HG →	-1.116	-0.632	<.001	.001	3	4
HNSC	CASS4 →	-0.713	-1.109	<.001	<.001	3	4
LUAD	NEK2 →	+1.161	+0.730	<.001	<.001	3	4
GBM	KIF14 →	+1.389	+0.823	<.001	<.001	3	4
LSCC	DIAPH3 →	+1.177	+1.086	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,986 associations by consensus.

IL22 vs TMPO — PDAC

Explore this scatter interactively →