IL22

Across TCGA patient cohorts, IL22 mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IL22-associated genes across cancer lineages are Gab2, JNK2, and Mre11. Each is linked with IL22 in more than 1 cancer types. Because this analysis shows association rather than direction, both IL22-to-partner and partner-to-IL22 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Gab2 grouped by IL22-low versus IL22-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IL22→partner) and Y-score (partner→IL22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Gab2 →	+0.492	+2.321	.006	.035	3	1
UCEC	JNK2 →	+0.266	+3.026	.007	.018	3	1
UCEC	Mre11 →	-0.098	-2.321	.023	.035	3	1
UCEC	N-Cadherin →	+0.232	+2.321	.029	.035	3	1
UCEC	Annexin-1 →	+0.719	+2.321	.006	.035	3	1
UCEC	Src_pY527 →	-0.595	-2.321	.005	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

Gab2 by IL22 expression — UCEC

Explore this box plot interactively →