IL22

Across TCGA cell cohorts, IL22 RNA expression is significantly associated with the mutation status of many other genes, with 363 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible IL22-associated genes across cancer lineages are SVEP1, MT-ND2, and RAI1. Each is linked with IL22 in more than 2 cancer types. Because this analysis shows association rather than direction, both IL22-to-partner and partner-to-IL22 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SVEP1 grouped by IL22-low versus IL22-high in BLOOD_Leukemia.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IL22→partner) and Y-score (partner→IL22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SVEP1 →	+3.762	+0.016	.007	<.001	3	3
SOFT_TISSUE	MT-ND2 →	+4.295	+0.123	.002	<.001	3	2
URINARY_TRACT	RAI1 →	+5.087	+0.023	.004	<.001	3	2
URINARY_TRACT	TPTE →	+5.087	+0.023	.004	<.001	3	2
URINARY_TRACT	ABCC8 →	+4.087	+0.017	.009	<.001	3	2
BLOOD_Leukemia	ZNF646 →	+3.762	+0.016	.007	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 363 associations by consensus.

SVEP1 by IL22 expression — BLOOD_Leukemia

Explore this box plot interactively →