IL1RN

Across TCGA pan-cancer cohorts, IL1RN Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated IL1RN data layer compared with 24 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher IL1RN Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated IL1RN expression acts as an unfavorable survival marker, although some lineages such as SKCM show a favorable association.

SKCM, ESCA, and LUAD are the cancer types where IL1RN Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	DFS	Median	All	0.492	0.191	.003	13	view →
ESCA	OS	Median	II,III,IV	0.206	0.686	.004	12	view →
LUAD	OS	Median	All	0.258	0.812	.004	12	view →
ACC	OS	Median	All	0.149	0.686	.047	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

IL1RN–SKCM (DFS)

Open the SKCM breakdown →