IL1RN

Across TCGA pan-cancer cohorts, IL1RN mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated IL1RN data layer compared with 24 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IL1RN mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated IL1RN expression acts as an unfavorable survival marker, although some lineages such as HNSC and UCEC show a favorable association.

HNSC, UCEC, and CCRCC are the cancer types where IL1RN mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Quartile	All	1.000	0.786	.002	45	view →
UCEC	OS	Median	II,III,IV	1.000	0.628	.013	22	view →
CCRCC	DFS	Tertile	II,III,IV	1.000	0.229	.011	15	view →
LUAD	OS	Tertile	All	0.337	0.852	.007	12	view →
LSCC	DFS	Tertile	II,III,IV	0.984	0.804	.041	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

IL1RN–HNSC (OS)

Open the HNSC breakdown →