IL1RAPL1

Across TCGA patient cohorts, IL1RAPL1 mutation is significantly associated with the RNA expression of many other genes, with 5,042 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IL1RAPL1-associated genes across cancer lineages are MED8, SNRNP25, and PTTG1. Each is linked with IL1RAPL1 in more than 3 cancer types. Because this analysis shows association rather than direction, both IL1RAPL1-to-partner and partner-to-IL1RAPL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MED8 grouped by IL1RAPL1-low versus IL1RAPL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IL1RAPL1→partner) and Y-score (partner→IL1RAPL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MED8 →	+0.258	+1.968	<.001	<.001	3	4
UCEC	SNRNP25 →	+0.480	+3.179	<.001	<.001	3	4
UCEC	PTTG1 →	+0.591	+2.595	<.001	<.001	3	4
UCEC	SLC25A33 →	+0.579	+1.760	<.001	<.001	3	4
SKCM	MRTO4 →	+0.375	+2.220	<.001	<.001	3	4
UCEC	UBE2T →	+0.577	+1.627	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,042 associations by consensus.

MED8 by IL1RAPL1 expression — UCEC

Explore this box plot interactively →