IL1RAPL1

Across TCGA patient cohorts, IL1RAPL1 mutation is significantly associated with the total protein of many other genes, with 68 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IL1RAPL1-associated genes across cancer lineages are MSH6, eEF2, and Rab25. Each is linked with IL1RAPL1 in more than 2 cancer types. Because this analysis shows association rather than direction, both IL1RAPL1-to-partner and partner-to-IL1RAPL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MSH6 grouped by IL1RAPL1-low versus IL1RAPL1-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IL1RAPL1→partner) and Y-score (partner→IL1RAPL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	MSH6 →	+0.500	+3.709	.003	<.001	3	3
UCEC	eEF2 →	+0.285	+1.999	.004	.008	3	3
UCEC	Rab25 →	-0.354	-2.584	<.001	<.001	3	3
UCEC	TFRC →	+0.504	+2.415	<.001	.002	3	3
UCEC	4E-BP1 →	+0.288	+3.999	<.001	<.001	3	3
SKCM	YAP_pS127 →	-0.280	-1.584	.045	.035	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 68 associations by consensus.

MSH6 by IL1RAPL1 expression — LUSC

Explore this box plot interactively →