IL1R1

Across TCGA patient cohorts, IL1R1 mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IL1R1-associated genes across cancer lineages are FoxM1, p38-MAPK, and Acetyl-a-Tubulin-Lys40. Each is linked with IL1R1 in more than 1 cancer types. Because this analysis shows association rather than direction, both IL1R1-to-partner and partner-to-IL1R1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by IL1R1-low versus IL1R1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IL1R1→partner) and Y-score (partner→IL1R1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.305	+3.807	.008	<.001	3	2
UCEC	p38-MAPK →	-0.202	-2.000	.006	.032	3	2
SKCM	Acetyl-a-Tubulin-Lys40 →	+0.699	+3.000	.001	<.001	3	1
SKCM	Bap1-c-4 →	+0.312	+3.321	.011	.009	3	1
SKCM	4E-BP1_pS65 →	+0.176	+2.321	.030	.006	3	1
SKCM	4E-BP1 →	+0.296	+3.321	.017	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

FoxM1 by IL1R1 expression — UCEC

Explore this box plot interactively →