IL1R1

Across TCGA pan-cancer cohorts, IL1R1 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated IL1R1 data layer compared with 7 for mutation status and 2 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher IL1R1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated IL1R1 expression acts as an unfavorable survival marker, although some lineages such as SKCM and HNSC show a favorable association.

KIRP, UVM, and LGG are the cancer types where IL1R1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Tertile	II,III,IV	0.433	0.783	<.001	110	view →
UVM	DFS	Tertile	III,IV	0.245	0.820	<.001	68	view →
LGG	DFS	Median	All	0.671	0.802	<.001	49	view →
SKCM	DFS	Median	All	0.671	0.563	.001	39	view →
KICH	OS	Tertile	II,III,IV	0.591	1.000	.002	32	view →
HNSC	DFS	Quartile	IV	0.707	0.502	.007	19	view →
LUAD	OS	Tertile	II,III,IV	0.879	0.702	.011	16	view →
BLCA	OS	Quartile	All	0.262	0.618	.021	15	view →
UCS	OS	Tertile	IV	0.767	0.387	.024	12	view →
DLBC	DFS	Median	All	0.606	1.000	.011	9	view →
GBM	DFS	Tertile	All	0.175	0.359	.009	9	view →
ESCA	DFS	Tertile	IV	0.242	0.628	.024	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

IL1R1–KIRP (OS)

Open the KIRP breakdown →