IL1R1

Across TCGA cell cohorts, IL1R1 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,738 significant associations in total. BONE shows the largest number of these associations.

The most reproducible IL1R1-associated GO terms across cancer lineages are Complement activation, classical pathway, T cell lineage commitment, and Protein targeting to vacuole involved in autophagy. Each is linked with IL1R1 in more than 15 cancer types. Because this analysis shows association rather than direction, both IL1R1-to-partner and partner-to-IL1R1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Complement activation, classical pathway grouped by IL1R1-low versus IL1R1-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IL1R1→partner) and Y-score (partner→IL1R1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Complement activation, classical pathway →	+1.609	+4.399	<.001	<.001	2	16
LUNG_NSCLC_LUSC	T cell lineage commitment →	+0.218	+2.019	<.001	<.001	3	14
SOFT_TISSUE	Protein targeting to vacuole involved in autophagy →	+0.193	+2.559	<.001	<.001	3	13
LUNG_NSCLC_LUSC	Alpha-beta T cell lineage commitment →	+0.216	+1.878	<.001	<.001	3	13
BONE	Oncostatin-M-mediated signaling pathway →	+0.331	+4.470	<.001	<.001	3	13
BONE	Response to topologically incorrect protein →	+0.123	+3.885	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,738 associations by consensus.

Complement activation, classical pathway by IL1R1 expression — BONE

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