IL1R1

Across TCGA cell cohorts, IL1R1 mutation is significantly associated with the RNA expression of many other genes, with 193 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible IL1R1-associated genes across cancer lineages are OR13D1, KRTAP9-8, and RPS6KA5. Each is linked with IL1R1 in more than 1 cancer types. Because this analysis shows association rather than direction, both IL1R1-to-partner and partner-to-IL1R1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR13D1 grouped by IL1R1-low versus IL1R1-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IL1R1→partner) and Y-score (partner→IL1R1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	OR13D1 →	+0.029	+4.269	.005	.005	3	1
LUNG_SCLC	KRTAP9-8 →	+0.050	+4.643	<.001	.004	3	1
LARGE_INTESTINE	RPS6KA5 →	+0.867	+3.212	.003	.006	3	1
LARGE_INTESTINE	MAST1 →	+1.134	+3.212	<.001	.006	3	1
LARGE_INTESTINE	DHX40 →	+0.640	+3.212	.003	.006	3	1
LARGE_INTESTINE	SLC38A1 →	+0.810	+3.212	.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 193 associations by consensus.

OR13D1 by IL1R1 expression — LUNG_SCLC

Explore this box plot interactively →