IL18BP

Across TCGA patient cohorts, IL18BP mutation is significantly associated with the RNA expression of many other genes, with 812 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IL18BP-associated genes across cancer lineages are GPC5-IT1, IGHD3-22, and LINC01895. Each is linked with IL18BP in more than 1 cancer types. Because this analysis shows association rather than direction, both IL18BP-to-partner and partner-to-IL18BP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GPC5-IT1 grouped by IL18BP-low versus IL18BP-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IL18BP→partner) and Y-score (partner→IL18BP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	GPC5-IT1 →	+0.053	+5.569	.004	.002	3	2
UCEC	IGHD3-22 →	+1.450	+1.954	.002	.003	3	2
UCEC	LINC01895 →	+0.318	+1.967	<.001	.002	3	2
CESC	GPR6 →	+0.034	+4.601	<.001	.004	3	1
CESC	MIR450A1 →	+0.460	+4.812	<.001	.006	3	1
CESC	MIR7-3 →	+0.275	+5.342	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 812 associations by consensus.

GPC5-IT1 by IL18BP expression — CESC

Explore this box plot interactively →