IL18

Across TCGA patient cohorts, IL18 mutation is significantly associated with the immune_cell of many other genes, with 3 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IL18-associated genes across cancer lineages are aDC, CD8+ Tem, and Th1 cells. Each is linked with IL18 in more than 1 cancer types. Because this analysis shows association rather than direction, both IL18-to-partner and partner-to-IL18 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, aDC grouped by IL18-low versus IL18-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IL18→partner) and Y-score (partner→IL18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	aDC →	+0.093	+2.815	.021	.036	3	1
UCEC	CD8+ Tem →	+0.004	+4.896	<.001	.036	3	1
UCEC	Th1 cells →	+0.101	+3.169	.048	.020	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

aDC by IL18 expression — UCEC

Explore this box plot interactively →