IL18

Across TCGA pan-cancer cohorts, IL18 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated IL18 data layer compared with 2 for mutation status and 2 for mass-spec protein.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher IL18 RNA is associated with better overall survival. In most high-consensus cancer types, elevated IL18 expression acts as an unfavorable survival marker, although some lineages such as SKCM and DLBC show a favorable association.

SKCM, PAAD, and DLBC are the cancer types where IL18 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Median	All	0.438	0.252	<.001	114	view →
PAAD	DFS	Median	All	0.198	0.391	<.001	63	view →
DLBC	DFS	Median	II,III,IV	0.911	0.469	.003	63	view →
LGG	DFS	Median	All	0.294	0.506	<.001	54	view →
ACC	DFS	Median	III,IV	0.092	0.601	.001	50	view →
UVM	DFS	Tertile	II,III,IV	0.340	0.680	<.001	47	view →
UCS	DFS	Tertile	IV	0.814	0.250	.024	24	view →
BRCA	DFS	Tertile	All	0.609	0.444	.003	22	view →
GBM	DFS	Quartile	All	0.227	0.509	.004	17	view →
SARC	OS	Quartile	All	0.852	0.693	.005	17	view →
MESO	OS	Median	All	0.637	0.442	.002	15	view →
ESCA	DFS	Quartile	All	0.677	0.422	.007	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

IL18–SKCM (OS)

Open the SKCM breakdown →