IL18

Across TCGA cell cohorts, IL18 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,004 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible IL18-associated GO terms across cancer lineages are Sleep, Positive regulation of NK T cell proliferation, and Regulation of T-helper 1 cell cytokine production. Each is linked with IL18 in more than 17 cancer types. Because this analysis shows association rather than direction, both IL18-to-partner and partner-to-IL18 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Sleep grouped by IL18-low versus IL18-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IL18→partner) and Y-score (partner→IL18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Sleep →	+2.485	+4.621	<.001	<.001	3	18
KIDNEY	Positive regulation of NK T cell proliferation →	+1.564	+2.656	<.001	<.001	3	14
KIDNEY	Regulation of T-helper 1 cell cytokine production →	+1.113	+3.305	.002	<.001	3	14
KIDNEY	Positive regulation of T-helper 1 cell cytokine production →	+1.113	+3.305	.002	<.001	3	14
LIVER	Positive regulation of granulocyte macrophage colony-stimulating factor production →	+1.946	+4.850	<.001	<.001	3	13
STOMACH	Positive regulation of natural killer cell proliferation →	+0.436	+3.153	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,004 associations by consensus.

Sleep by IL18 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →