IL17F

Across TCGA patient cohorts, IL17F mutation is significantly associated with the RNA expression of many other genes, with 490 significant associations in total. LUSC shows the largest number of these associations.

The most reproducible IL17F-associated genes across cancer lineages are MIR6088, RN7SKP38, and RN7SL567P. Each is linked with IL17F in more than 1 cancer types. Because this analysis shows association rather than direction, both IL17F-to-partner and partner-to-IL17F results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR6088 grouped by IL17F-low versus IL17F-high in LGG.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IL17F→partner) and Y-score (partner→IL17F) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LGG	MIR6088 →	+0.907	+5.039	<.001	.009	3	2
UCEC	RN7SKP38 →	+0.458	+3.073	.007	.003	3	2
UCEC	RN7SL567P →	+0.108	+3.242	.007	.007	3	2
HNSC	LINC01803 →	+0.089	+5.124	<.001	.008	3	2
LUSC	RAB28P4 →	+0.072	+5.005	<.001	.002	3	2
SKCM	MIR1270 →	+0.491	+2.728	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 490 associations by consensus.

MIR6088 by IL17F expression — LGG

Explore this box plot interactively →