IL17F

Across TCGA pan-cancer cohorts, IL17F RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of IL17F’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where IL17F RNA is repressed in tumor relative to normal tissue. In most cancer types IL17F is over-expressed in tumor, although a few such as HNSC and KICH show the opposite, repressed pattern.

HNSC, KICH, and LIHC are the cancer types where IL17F tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IL17F RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	II,III,IV	−0.590	<.001	10	view →
KICH	All	All	−0.082	<.001	6	view →
LIHC	All	II,III,IV	+0.031	.003	6	view →
COAD	Female	All	+0.149	.002	4	view →
READ	All	All	+0.407	.032	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

IL17F–HNSC

Open the HNSC breakdown →