IL17F

Across TCGA cell cohorts, IL17F mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible IL17F-associated genes across cancer lineages are DEFB123, ACSM6, and CFHR2. Each is linked with IL17F in more than 1 cancer types. Because this analysis shows association rather than direction, both IL17F-to-partner and partner-to-IL17F results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DEFB123 grouped by IL17F-low versus IL17F-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IL17F→partner) and Y-score (partner→IL17F) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	DEFB123 →	+0.103	+5.643	<.001	.002	3	1
LARGE_INTESTINE	ACSM6 →	+0.031	+4.584	<.001	<.001	3	1
LARGE_INTESTINE	CFHR2 →	+0.046	+4.437	<.001	.004	3	1
LUNG_NSCLC_LUAD	DMRTB1 →	+0.006	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	OPRPN →	+0.030	+4.887	.005	.009	3	1
LUNG_NSCLC_LUAD	OR1L3 →	+0.028	+4.887	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

DEFB123 by IL17F expression — LUNG_SCLC

Explore this box plot interactively →