IL17C

Across TCGA patient cohorts, IL17C mutation is significantly associated with the RNA expression of many other genes, with 77 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IL17C-associated genes across cancer lineages are DEFB105A, RPL3P11, and PFN1P12. Each is linked with IL17C in more than 1 cancer types. Because this analysis shows association rather than direction, both IL17C-to-partner and partner-to-IL17C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DEFB105A grouped by IL17C-low versus IL17C-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IL17C→partner) and Y-score (partner→IL17C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	DEFB105A →	+0.102	+5.579	<.001	.001	3	1
CESC	RPL3P11 →	+0.060	+4.567	<.001	.001	3	1
CESC	PFN1P12 →	+0.102	+3.705	<.001	.008	3	1
CESC	VDAC1P12 →	+0.036	+4.384	<.001	.008	3	1
CESC	HBBP1 →	+0.225	+4.735	<.001	.001	3	1
CESC	RPL12P49 →	+0.360	+3.705	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 77 associations by consensus.

DEFB105A by IL17C expression — CESC

Explore this box plot interactively →