IL17C

Across TCGA cell cohorts, IL17C mutation is significantly associated with the mutation status of many other genes, with 992 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible IL17C-associated genes across cancer lineages are EHBP1L1, SLC39A13, and TMPRSS6. Each is linked with IL17C in more than 2 cancer types. Because this analysis shows association rather than direction, both IL17C-to-partner and partner-to-IL17C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EHBP1L1 grouped by IL17C-low versus IL17C-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IL17C→partner) and Y-score (partner→IL17C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	EHBP1L1 →	+2.894	+4.432	.005	.005	1	3
UPPER_AERODIGESTIVE_TRACT	SLC39A13 →	+5.392	+5.392	.004	.004	1	2
UPPER_AERODIGESTIVE_TRACT	TMPRSS6 →	+4.392	+4.954	.008	.008	1	2
UPPER_AERODIGESTIVE_TRACT	MYBPC1 →	+4.392	+4.954	.008	.008	1	2
SKIN	RNF40 →	+5.824	+5.824	.002	.002	1	2
SKIN	FOLR1 →	+5.824	+5.824	.002	.002	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 992 associations by consensus.

EHBP1L1 by IL17C expression — BLOOD_Leukemia

Explore this box plot interactively →