IL17B

Across TCGA patient cohorts, IL17B mutation is significantly associated with the RNA expression of many other genes, with 108 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IL17B-associated genes across cancer lineages are RNU6-966P, MIR409, and RNU4-20P. Each is linked with IL17B in more than 1 cancer types. Because this analysis shows association rather than direction, both IL17B-to-partner and partner-to-IL17B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-966P grouped by IL17B-low versus IL17B-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IL17B→partner) and Y-score (partner→IL17B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	RNU6-966P →	+0.341	+7.640	<.001	.009	3	2
BRCA	MIR409 →	+0.273	+5.442	<.001	.002	3	2
HNSC	RNU4-20P →	+0.379	+7.954	<.001	.008	3	2
UCEC	MIR3198-1 →	+0.792	+3.416	<.001	.001	3	2
STAD	RNA5SP200 →	+0.323	+5.678	.001	.003	3	2
SKCM	STSP1 →	+0.023	+3.943	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 108 associations by consensus.

RNU6-966P by IL17B expression — BLCA

Explore this box plot interactively →