IL17A

Across TCGA patient cohorts, IL17A protein abundance is significantly associated with the protein abundance of many other proteins, with 1,532 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible IL17A-associated proteins across cancer lineages are SMG6_T301, SMG6_S299, and DCP1B_S283. Each is linked with IL17A in more than 3 cancer types. Because this analysis shows association rather than direction, both IL17A-to-partner and partner-to-IL17A results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IL17A versus SMG6_T301 in LSCC, with a Pearson correlation of 1.00.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (IL17A→partner) and Y-score (partner→IL17A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SMG6_T301 →	+1.614	+1.614	<.001	<.001	3	2
LUAD	SMG6_S299 →	+1.509	+1.509	.005	.005	1	4
HNSC	DCP1B_S283 →	+0.675	+1.335	<.001	<.001	3	2
HNSC	SMG6_S303 →	+0.948	+0.948	<.001	<.001	3	1
HNSC	SRRM1_S431 →	+0.614	+0.682	.001	.004	2	2
HNSC	SRSF2_S26 →	+0.474	+1.047	.002	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,532 associations by consensus.

IL17A vs SMG6_T301 — LSCC

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