IL17A

Across TCGA pan-cancer cohorts, IL17A RNA is linked to patient survival in 18 of 34 cancer types, making it the most broadly survival-associated IL17A data layer compared with 4 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher IL17A RNA is associated with worse overall survival. In most high-consensus cancer types, elevated IL17A expression acts as an unfavorable survival marker, although some lineages such as HNSC and OV show a favorable association.

SKCM, ACC, and HNSC are the cancer types where IL17A RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Tertile	All	0.611	0.802	<.001	111	view →
ACC	DFS	Tertile	II,III,IV	0.010	0.582	<.001	108	view →
HNSC	OS	Tertile	All	0.530	0.333	<.001	73	view →
DLBC	OS	Quartile	II,III,IV	0.307	0.953	.001	57	view →
UCS	DFS	Tertile	IV	0.132	0.718	.002	54	view →
OV	DFS	Tertile	All	0.461	0.365	.022	48	view →
COAD	OS	Median	All	0.844	0.757	.010	35	view →
THCA	DFS	Tertile	II,III,IV	0.915	0.664	.011	33	view →
BLCA	OS	Tertile	IV	0.700	0.259	.006	26	view →
CHOL	DFS	Tertile	All	0.843	0.339	.034	18	view →
STAD	DFS	Median	III,IV	0.514	0.656	.017	16	view →
GBM	OS	Tertile	All	0.089	0.415	.021	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 18 lineages.

IL17A–SKCM (OS)

Open the SKCM breakdown →