IL17A

Across TCGA patient cohorts, IL17A mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible IL17A-associated genes across cancer lineages are YB-1_pS102, ATM, and Annexin-1. Each is linked with IL17A in more than 1 cancer types. Because this analysis shows association rather than direction, both IL17A-to-partner and partner-to-IL17A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, YB-1_pS102 grouped by IL17A-low versus IL17A-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IL17A→partner) and Y-score (partner→IL17A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	YB-1_pS102 →	+0.377	+2.871	<.001	.033	3	2
UCEC	ATM →	-0.769	-2.986	.001	.035	3	2
UCEC	Annexin-1 →	+0.738	+2.827	.010	.035	3	1
SKCM	ACC_pS79 →	+0.327	+3.000	.049	.036	3	1
SKCM	Ku80 →	+0.379	+3.000	.016	.036	1	2
SKCM	Caspase-7-cleavedD198 →	-0.733	-3.000	.027	.036	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

YB-1_pS102 by IL17A expression — LUSC

Explore this box plot interactively →