IL15

Mutation & survival
SurvivalMutationKaplan–Meier · TCGA cohorts

Across TCGA pan-cancer cohorts, IL15 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated IL15 data layer compared with 19 for mass-spec protein.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher IL15 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated IL15 expression acts as an unfavorable survival marker.

LUAD, UCEC, and COAD are the cancer types where IL15 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.
LineageMeasureSplitStageAUC1
high
AUC2
low
pSampling consensus
LUADDFSMedianIV0.3420.893<.0016view →
UCECOSMedianIV0.2310.592.0366view →
COADDFSMedianAll0.2360.696.0223view →
Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

IL15–LUAD (DFS)

Kaplan–Meier survival curve for IL15 mutant vs wild-type samples in LUAD.

Open the LUAD breakdown →

Exploration