IL15

Across TCGA pan-cancer cohorts, IL15 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of IL15’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where IL15 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types IL15 is over-expressed in tumor, although a few such as LUAD and THCA show the opposite, repressed pattern.

KIRC, HNSC, and LUAD are the cancer types where IL15 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IL15 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	IV	+0.984	<.001	11	view →
HNSC	All	All	+0.548	<.001	10	view →
LUAD	Female	III,IV	−0.943	<.001	7	view →
THCA	Male	All	−0.671	<.001	7	view →
LUSC	All	All	−0.707	<.001	6	view →
BRCA	All	III,IV	−0.303	.009	6	view →
UCEC	All	All	−0.778	<.001	4	view →
CHOL	Female	All	+1.853	<.001	3	view →
COAD	All	All	−0.291	.006	3	view →
LIHC	All	All	+0.247	.011	3	view →
ESCA	All	All	+0.892	.004	2	view →
BLCA	All	IV	−0.449	.014	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

IL15–KIRC

Open the KIRC breakdown →