IL15

Across TCGA patient cohorts, IL15 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IL15-associated genes across cancer lineages are eEF2, PDCD4, and GSK3-a-b. Each is linked with IL15 in more than 1 cancer types. Because this analysis shows association rather than direction, both IL15-to-partner and partner-to-IL15 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by IL15-low versus IL15-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IL15→partner) and Y-score (partner→IL15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.444	+3.000	.031	.037	3	1
UCEC	PDCD4 →	-0.716	-3.000	.008	.037	3	1
UCEC	GSK3-a-b →	+0.159	+3.000	.042	.037	2	1
UCEC	PTEN →	-0.547	-3.000	.017	.037	2	1
UCEC	eIF4E →	+0.279	+3.000	.022	.037	1	1
UCEC	STAT3_pY705 →	-0.508	-3.000	<.001	.037	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

eEF2 by IL15 expression — UCEC

Explore this box plot interactively →