IL15

Across TCGA cell cohorts, IL15 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible IL15-associated genes across cancer lineages are HHLA1, PRR20B, and PRR20A. Each is linked with IL15 in more than 1 cancer types. Because this analysis shows association rather than direction, both IL15-to-partner and partner-to-IL15 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HHLA1 grouped by IL15-low versus IL15-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IL15→partner) and Y-score (partner→IL15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	HHLA1 →	+0.067	+4.191	<.001	.007	3	1
BLOOD_Lymphoma	PRR20B →	+0.119	+4.643	<.001	.005	3	1
BLOOD_Lymphoma	PRR20A →	+0.119	+4.643	<.001	.005	3	1
BLOOD_Lymphoma	PRR20D →	+0.119	+4.643	<.001	.005	3	1
BLOOD_Lymphoma	PRR20E →	+0.119	+4.643	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

HHLA1 by IL15 expression — BLOOD_Lymphoma

Explore this box plot interactively →