IL12RB2

Across TCGA patient cohorts, IL12RB2 mutation is significantly associated with the RNA expression of many other genes, with 2,261 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IL12RB2-associated genes across cancer lineages are RNU1-80P, RNU6-650P, and CENPU. Each is linked with IL12RB2 in more than 3 cancer types. Because this analysis shows association rather than direction, both IL12RB2-to-partner and partner-to-IL12RB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU1-80P grouped by IL12RB2-low versus IL12RB2-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IL12RB2→partner) and Y-score (partner→IL12RB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RNU1-80P →	+0.244	+5.378	<.001	.006	3	4
LIHC	RNU6-650P →	+0.260	+4.878	<.001	.005	3	4
UCEC	CENPU →	+0.646	+1.906	.001	.001	3	3
UCEC	ABHD10 →	+0.382	+2.606	<.001	<.001	3	3
UCEC	LARP1BP3 →	+0.055	+2.570	.003	.001	3	3
HNSC	MIR153-2 →	+0.244	+5.035	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,261 associations by consensus.

RNU1-80P by IL12RB2 expression — BRCA

Explore this box plot interactively →