IL12B

Across TCGA cell cohorts, IL12B RNA expression is significantly associated with the go_rna of many other GO terms, with 919 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible IL12B-associated GO terms across cancer lineages are Regulation of protein modification by small protein conjugation or removal, Regulation of post-translational protein modification, and Cellular response to environmental stimulus. Each is linked with IL12B in more than 8 cancer types. Because this analysis shows association rather than direction, both IL12B-to-partner and partner-to-IL12B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of protein modification by small protein conjugation or removal grouped by IL12B-low versus IL12B-high in LARGE_INTESTINE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IL12B→partner) and Y-score (partner→IL12B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Regulation of protein modification by small protein conjugation or removal →	+0.040	+0.039	<.001	.007	3	9
LARGE_INTESTINE	Regulation of post-translational protein modification →	+0.038	+0.039	.001	.007	3	8
LARGE_INTESTINE	Cellular response to environmental stimulus →	+0.042	+0.055	<.001	.002	3	7
LARGE_INTESTINE	Cellular response to abiotic stimulus →	+0.042	+0.055	<.001	.002	3	7
OVARY	Cytoplasmic translation →	+0.076	+0.034	<.001	.006	3	7
LARGE_INTESTINE	Cellular senescence →	+0.069	+0.055	<.001	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 919 associations by consensus.

Regulation of protein modification by small protein conjugation or removal by IL12B expression — LARGE_INTESTINE

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