IL12A

Across TCGA patient cohorts, IL12A mutation is significantly associated with the immune_cell of many other genes, with 4 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IL12A-associated genes across cancer lineages are lymphatic Endothelial cells, naive B-cells, and Endothelial cells. Each is linked with IL12A in more than 1 cancer types. Because this analysis shows association rather than direction, both IL12A-to-partner and partner-to-IL12A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, lymphatic Endothelial cells grouped by IL12A-low versus IL12A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IL12A→partner) and Y-score (partner→IL12A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	lymphatic Endothelial cells →	-0.022	-3.281	.042	.010	3	2
READ	naive B-cells →	+0.023	+5.039	<.001	.008	3	1
UCEC	Endothelial cells →	-0.035	-2.991	.046	.036	3	1
UCEC	Macrophages M2 →	+0.012	+2.194	.014	.034	2	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

lymphatic Endothelial cells by IL12A expression — UCEC

Explore this box plot interactively →