IL12A

Across TCGA pan-cancer cohorts, IL12A RNA is linked to patient survival in 18 of 34 cancer types, making it the most broadly survival-associated IL12A data layer compared with 2 for mutation status.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher IL12A RNA is associated with better overall survival. In most high-consensus cancer types, elevated IL12A expression acts as an unfavorable survival marker, although some lineages such as SKCM and READ show a favorable association.

SKCM, KIRP, and READ are the cancer types where IL12A RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Median	All	0.425	0.243	<.001	103	view →
KIRP	DFS	Quartile	All	0.332	0.917	.001	60	view →
READ	DFS	Tertile	IV	0.822	0.341	.002	59	view →
KIRC	DFS	Tertile	IV	0.257	0.645	<.001	46	view →
KICH	DFS	Quartile	All	0.557	1.000	<.001	43	view →
LUSC	DFS	Median	III,IV	0.488	0.929	.003	34	view →
LIHC	DFS	Median	All	0.379	0.494	.001	32	view →
UCEC	DFS	Median	II,III,IV	0.660	0.801	.007	30	view →
CESC	OS	Median	All	0.689	0.502	.008	24	view →
MESO	DFS	Quartile	II,III,IV	0.308	0.762	.006	21	view →
OV	DFS	Quartile	All	0.492	0.614	.006	14	view →
STAD	OS	Quartile	IV	0.187	0.637	.014	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 18 lineages.

IL12A–SKCM (OS)

Open the SKCM breakdown →