IL12A

Across TCGA cell cohorts, IL12A RNA expression is significantly associated with the go_rna of many other GO terms, with 4,124 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible IL12A-associated GO terms across cancer lineages are Positive regulation of NK T cell activation, Positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, and T cell lineage commitment. Each is linked with IL12A in more than 10 cancer types. Because this analysis shows association rather than direction, both IL12A-to-partner and partner-to-IL12A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of NK T cell activation grouped by IL12A-low versus IL12A-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IL12A→partner) and Y-score (partner→IL12A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Positive regulation of NK T cell activation →	-0.335	-1.008	.001	.001	1	11
OVARY	Positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target →	-0.205	-0.981	.001	.002	3	9
BLOOD_Lymphoma	T cell lineage commitment →	+0.139	+1.735	<.001	<.001	3	9
BREAST	Regulation of NK T cell activation →	-0.179	-0.901	.005	.001	3	8
STOMACH	Positive regulation of receptor signaling pathway via JAK-STAT →	-0.113	-0.988	<.001	<.001	2	9
URINARY_TRACT	Negative regulation of negative chemotaxis →	+1.276	+1.027	.001	.003	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,124 associations by consensus.

Positive regulation of NK T cell activation by IL12A expression — BONE

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