IL12A-AS1

Across TCGA pan-cancer cohorts, IL12A-AS1 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated IL12A-AS1 data layer compared with 7 for mutation status.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher IL12A-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated IL12A-AS1 expression acts as an unfavorable survival marker, although some lineages such as LUAD and HNSC show a favorable association.

KIRC, UVM, and KICH are the cancer types where IL12A-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Quartile	IV	0.324	0.722	<.001	87	view →
UVM	DFS	Tertile	II,III,IV	0.480	0.794	.003	60	view →
KICH	DFS	Quartile	All	0.476	1.000	<.001	53	view →
KIRP	OS	Tertile	All	0.387	0.775	<.001	32	view →
MESO	OS	Quartile	II,III,IV	0.207	0.441	.012	23	view →
BRCA	DFS	Quartile	II,III,IV	0.921	0.970	.016	18	view →
LUAD	OS	Tertile	III,IV	0.465	0.243	.018	18	view →
HNSC	DFS	Tertile	III,IV	0.677	0.497	.004	15	view →
LUSC	DFS	Median	III,IV	0.489	0.942	.024	14	view →
THCA	OS	Tertile	II,III,IV	0.759	1.000	.009	14	view →
THYM	DFS	Quartile	All	0.721	0.978	.007	13	view →
LIHC	DFS	Quartile	II,III,IV	0.168	0.544	<.001	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

IL12A-AS1–KIRC (DFS)

Open the KIRC breakdown →