IL12A-AS1

Across TCGA pan-cancer cohorts, IL12A-AS1 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of IL12A-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where IL12A-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types IL12A-AS1 is over-expressed in tumor, although a few such as HNSC and LUAD show the opposite, repressed pattern.

HNSC, LUAD, and COAD are the cancer types where IL12A-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IL12A-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	−0.675	<.001	12	view →
LUAD	Female	III,IV	−0.212	.003	5	view →
COAD	All	All	−0.128	.006	4	view →
BRCA	Female	II,III,IV	+0.095	<.001	4	view →
THCA	All	All	+0.157	.007	3	view →
KICH	All	All	−0.038	.006	3	view →
READ	All	All	−0.307	.023	2	view →
LUSC	Male	III,IV	−0.097	.007	2	view →
CHOL	All	All	+0.144	.039	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

IL12A-AS1–HNSC

Open the HNSC breakdown →