IL12A-AS1

Across TCGA pan-cancer cohorts, IL12A-AS1 Mutation is linked to patient survival in 7 of 34 cancer types, making it a survival-associated IL12A-AS1 data layer compared with 26 for mass-spec protein.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher IL12A-AS1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated IL12A-AS1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and SKCM show a favorable association.

BRCA, UCEC, and HNSC are the cancer types where IL12A-AS1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	OS	Median	All	0.177	0.580	<.001	24	view →
UCEC	DFS	Median	II,III,IV	0.928	0.434	.017	22	view →
HNSC	DFS	Median	All	0.315	0.606	.011	15	view →
COAD	DFS	Median	All	0.443	0.783	.003	12	view →
STAD	OS	Median	II,III,IV	0.258	0.662	.032	8	view →
ESCA	OS	Median	All	0.198	0.685	.001	6	view →
SKCM	DFS	Median	III,IV	0.761	0.449	.012	6	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

IL12A-AS1–BRCA (OS)

Open the BRCA breakdown →