IL10RA

Across TCGA patient cohorts, IL10RA mutation is significantly associated with the RNA expression of many other genes, with 2,880 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IL10RA-associated genes across cancer lineages are ENOSF1, OXSM, and DDAH1. Each is linked with IL10RA in more than 2 cancer types. Because this analysis shows association rather than direction, both IL10RA-to-partner and partner-to-IL10RA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ENOSF1 grouped by IL10RA-low versus IL10RA-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IL10RA→partner) and Y-score (partner→IL10RA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ENOSF1 →	+0.480	+2.914	.001	.001	3	3
UCEC	OXSM →	+0.397	+2.885	<.001	<.001	3	2
UCEC	DDAH1 →	+0.778	+2.895	<.001	<.001	3	2
UCEC	DGKE →	+0.381	+2.000	.009	.003	3	2
UCEC	BTG3 →	+0.514	+2.595	.004	.005	3	2
UCEC	MRPL39 →	+0.458	+3.111	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,880 associations by consensus.

ENOSF1 by IL10RA expression — UCEC

Explore this box plot interactively →