IL10RA

Across TCGA pan-cancer cohorts, IL10RA RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of IL10RA’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where IL10RA RNA is more highly expressed in tumor relative to normal tissue. In most cancer types IL10RA is over-expressed in tumor, although a few such as COAD and LUSC show the opposite, repressed pattern.

KIRC, COAD, and LUSC are the cancer types where IL10RA tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IL10RA RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	All	+2.330	<.001	12	view →
COAD	All	III,IV	−1.118	<.001	10	view →
LUSC	Male	II,III,IV	−1.558	<.001	8	view →
KIRP	Male	All	+1.497	<.001	8	view →
LUAD	All	II,III,IV	−0.671	<.001	6	view →
BLCA	All	All	−0.817	.010	5	view →
PAAD	All	All	−1.954	.032	2	view →
HNSC	Female	II,III,IV	+0.815	.020	2	view →
UCEC	All	All	−0.670	.011	2	view →
READ	Female	All	−1.359	.036	1	view →
ESCA	All	All	+1.145	.045	1	view →
LIHC	Male	All	−0.592	.009	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

IL10RA–KIRC

Open the KIRC breakdown →