IL10RA

Across TCGA cell cohorts, IL10RA mutation is significantly associated with the RNA expression of many other genes, with 284 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible IL10RA-associated genes across cancer lineages are SERPINA7, C1orf158, and GIMD1. Each is linked with IL10RA in more than 1 cancer types. Because this analysis shows association rather than direction, both IL10RA-to-partner and partner-to-IL10RA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SERPINA7 grouped by IL10RA-low versus IL10RA-high in BLOOD_Myeloma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IL10RA→partner) and Y-score (partner→IL10RA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	SERPINA7 →	+0.459	+4.807	<.001	.006	3	1
BLOOD_Myeloma	C1orf158 →	+0.053	+4.807	<.001	.006	3	1
BLOOD_Myeloma	GIMD1 →	+0.016	+4.807	<.001	.006	3	1
LARGE_INTESTINE	GCAT →	+1.534	+3.212	<.001	.006	3	1
LARGE_INTESTINE	ASPN →	+0.039	+2.600	<.001	.006	3	1
LARGE_INTESTINE	GTF2H3 →	+0.681	+3.299	.004	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 284 associations by consensus.

SERPINA7 by IL10RA expression — BLOOD_Myeloma

Explore this box plot interactively →