IKZF5

Across TCGA patient cohorts, IKZF5 mutation is significantly associated with the RNA expression of many other genes, with 1,903 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IKZF5-associated genes across cancer lineages are RNA5SP411, MIR1225, and SPRYD7P1. Each is linked with IKZF5 in more than 1 cancer types. Because this analysis shows association rather than direction, both IKZF5-to-partner and partner-to-IKZF5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP411 grouped by IKZF5-low versus IKZF5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IKZF5→partner) and Y-score (partner→IKZF5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP411 →	+1.693	+2.393	<.001	.002	3	2
UCEC	MIR1225 →	+0.225	+3.153	<.001	.006	3	2
SKCM	SPRYD7P1 →	+0.057	+4.867	<.001	.005	3	1
SKCM	FABP5P13 →	+0.182	+5.163	<.001	.001	3	1
SKCM	MTND1P2 →	+0.068	+4.352	.007	.007	3	1
SKCM	RN7SL790P →	+0.175	+4.680	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,903 associations by consensus.

RNA5SP411 by IKZF5 expression — UCEC

Explore this box plot interactively →